Category: Uncategorized
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Modelling of ZIKA proteases
Disclaimer: This blog is made public in order to inspire a new generation of enthusiastic people to start working on this neglected disease as soon as possible. I was doing some side-project especially with flaviviruses and the drug discovery targeting flavivirus proteases. That’s why ZIKA break into the scene of my research as ZIKA is
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New review on “Flap Dynamics”
Our latest review deals with computational study on “Flap dynamics” across proteases has been accepted in Chemical Biology & Drug Design.
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Drug re-purposing by targeting Dengue and CHIKV
One of our long standing dream to use drug re-purpose or repositioning strategy on neglected tropical diseases such as Dengue or CHIKV was finally successful with the publication of the latest article entitled “Reaching beyond HIV/HCV: nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus” in RSC Advances (LINK).
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New review on Chikungunya inhibitors from Natural Sources
One of our new review entitled “Chikungunya Virus (CHIKV) Inhibitors from Natural Sources: A Medicinal Chemistry Perspective“ accepted recently in Journal of Natural Medicines (Impact factor: 1.447). This review highlights all current efforts to identify novel CHIKV inhibitors from natural resources.
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New article accepted in Cell Biochemistry and Biophysics
Our new article entitled “Single Active Site Mutation Causes Serious Resistance of HIV Reverse Transcriptase to Lamivudine: Insight from Multiple Molecular Dynamics Simulations” accepted recently in Cell Biochemistry and Biophysics which unveils the HIV-1 reverse transcriptase’s mechanism of resistance to lamivudine due to M184I mutation. A multiple molecular dynamics simulation approach was employed in this
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Welcome to the homepage of Soumendranath Bhakat whose research interest is within the exciting field of biology, chemistry and computational applications. This webpage not only highlights current research interests, publications but also contains links of several softwares and servers used in the field of computational biology, molecular modelling and drug discovery. My current focus lies
Life in Computational Biology 